Year : 2016  |  Volume : 19  |  Issue : 3  |  Page : 475--480

Intraoperative conversion to on-pump coronary artery bypass grafting is independently associated with higher mortality in patients undergoing off-pump coronary artery bypass grafting: A propensity-matched analysis


Deepak Prakash Borde1, Balaji Asegaonkar1, Pramod Apsingekar1, Sujeet Khade1, Savni Futane1, Bapu Khodve1, Ajita Annachhatre1, Manish Puranik2, Sayaji Sargar2, Yogesh Belapurkar3, Anand Deodhar4, Antony George5, Shreedhar Joshi6 
1 Ozone Anesthesia Group, Aurangabad, Maharashtra, India
2 Seth Nandlal Dhoot Hospital, Aurangabad, Maharashtra, India
3 MGM College and Hospital, Mumbai, Maharashtra, India
4 United CIIGMA Hospital, Aurangabad, Maharashtra, India
5 Fortis Hospital, Bengaluru, Karnataka, India
6 Nayati Hospital, Mathura, Uttar Pradesh, India

Correspondence Address:
Deepak Prakash Borde
Ozone Anesthesia Group, First Floor, United CIIGMA Hospital, Aurangabad, Maharashtra
India

Context: One of the main limitations of off-pump coronary artery bypass grafting (OPCAB) is the occasional need for intraoperative conversion (IOC) to on-pump coronary artery bypass grafting. IOC is associated with a significantly increased risk of mortality and postoperative morbidity. The impact of IOC on outcome cannot be assessed by a randomized control design. Aims: The objective of this study was to analyze the incidence, risk factors, and impact of IOC on the outcome in patients undergoing OPCAB. Settings and Design: Three tertiary care level hospitals; retrospective observational study. Subjects and Methods: This retrospective observational study included 1971 consecutive patients undergoing  OPCAB from January 2012 to October 2015 at three tertiary care level hospitals by four surgeons. The incidence, patient characteristics, cause of IOC, and its impact on outcome were studied. Statistical Analysis Used: The cohort was divided into two groups according to IOC. Univariate logistic regression was performed to describe the predictors of IOC. Variables that were found to be significant in univariate analysis were introduced into multivariate model, and adjusted odds ratio (OR) was calculated. To further assess the independent effect of IOC on mortality, propensity score matching with a 5:1 ratio of non-IOC to IOC was performed. Results: The overall all-cause in-hospital mortality was 2.6%. IOC was needed in 128 (6.49%) patients. The mortality in the IOC group was significantly higher than non-IOC group (21 of 128 [16.4%] vs. 31 of 1843 [1.7%], P = 0.0001). The most common cause for IOC was hemodynamic disturbances during grafting to the obtuse marginal artery (51/128; 40%). On multivariate logistic regression analysis, left main disease, pulmonary hypertension, and mitral regurgitation independently predicted IOC. We obtained a propensity-matched sample of 692 patients (No IOC 570; IOC 122), and IOC had OR of 16.26 (confidence interval 6.3-41; P < 0.0001) for mortality in matched population. Conclusions: Emergency IOC increases odds for mortality by 16-fold. Hence, identification of patients at higher risk of IOC may improve the outcome.


How to cite this article:
Borde DP, Asegaonkar B, Apsingekar P, Khade S, Futane S, Khodve B, Annachhatre A, Puranik M, Sargar S, Belapurkar Y, Deodhar A, George A, Joshi S. Intraoperative conversion to on-pump coronary artery bypass grafting is independently associated with higher mortality in patients undergoing off-pump coronary artery bypass grafting: A propensity-matched analysis.Ann Card Anaesth 2016;19:475-480


How to cite this URL:
Borde DP, Asegaonkar B, Apsingekar P, Khade S, Futane S, Khodve B, Annachhatre A, Puranik M, Sargar S, Belapurkar Y, Deodhar A, George A, Joshi S. Intraoperative conversion to on-pump coronary artery bypass grafting is independently associated with higher mortality in patients undergoing off-pump coronary artery bypass grafting: A propensity-matched analysis. Ann Card Anaesth [serial online] 2016 [cited 2021 Feb 27 ];19:475-480
Available from: https://www.annals.in/article.asp?issn=0971-9784;year=2016;volume=19;issue=3;spage=475;epage=480;aulast=Borde;type=0