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Table of Contents
Year : 2020  |  Volume : 23  |  Issue : 2  |  Page : 246
Abnormal mitral valve apparatus is not an indication for mitral valve replacement in hypertrophic obstructive cardiomyopathy

Center for Hypertrophic Cardiomyopathy, Amrita Institute of Medical Sciences and Research Center, Amrita University, Kochi, Kerala, India

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Date of Submission07-Aug-2018
Date of Acceptance06-Nov-2018
Date of Web Publication06-Apr-2020

How to cite this article:
Varma PK, Ahamed H. Abnormal mitral valve apparatus is not an indication for mitral valve replacement in hypertrophic obstructive cardiomyopathy. Ann Card Anaesth 2020;23:246

How to cite this URL:
Varma PK, Ahamed H. Abnormal mitral valve apparatus is not an indication for mitral valve replacement in hypertrophic obstructive cardiomyopathy. Ann Card Anaesth [serial online] 2020 [cited 2021 Oct 21];23:246. Available from:

The Editor,

We read with interest the article by Aggarwal et al.[1] about the intraoperative echocardiography detection of abnormal mitral valve apparatus in a patient scheduled for surgery for hypertrophic obstructive cardiomyopathy in the latest issue of Annals. The authors need to be congratulated for detecting the various abnormalities of the mitral valve apparatus by intraoperative transesophageal echocardiography; however, we feel that the concomitant mitral valve replacement along with septal myectomy was probably unwarranted.

The abnormalities of mitral valve, as the authors rightly pointed out, are a phenotypical expression of the disease and are increasingly recognized as an important component of left ventricular outflow tract obstruction, especially when the thickness of interventricular septum is <18 mm.[2],[3] The large majority of patients with obstructive hypertrophic cardiomyopathy (HCM) have elongated anterior and posterior mitral leaflets. In obstructive HCM, the anterior mitral leaflet length averages 34 mm versus 24 mm in a normal heart. These elongated leaflets protrude into the left ventricle well above the plane of mitral annulus (26 mm compared to 13 mm in normal hearts) when it is viewed from the apical views at systolic coaptation in transthoracic echocardiography[2] and is called the “nightcap” mitral valve. The residual portion of anterior leaflet beyond the point of coaptation is not constrained by the left ventricle–left atrium pressure difference; rather, it is only bounded by the left ventricle and thus freely moves with the left ventricular flow, even at low velocities.[2]

These abnormalities are easily detected in cardiac magnetic resonance imaging (MRI) preoperatively; incorporating cardiac MRI[4] in the diagnostic workup algorithm has become the standard of care in most HCM centers including ours, so that intraoperative diagnostic surprises are avoided and enables proper preoperative planning. Even then, transaortic extended septal myectomy is the first step of surgery. In most patients, mitral regurgitation related to systolic anterior motion is relieved through extended myectomy. The anterior mitral leaflet plication and release of papillary muscles[5] are added to myectomy by some surgeons (resection/plication/release). We routinely perform horizontal plication of anterior mitral leaflet if it is above 32 mm in length. Concomitant mitral valve surgery is rarely necessary unless intrinsic mitral valve disease is present. When mitral valve procedures are required, repair is preferred because of improved survival compared with replacement. Every effort should be made by surgeons to conserve the mitral valve, as mitral valve replacement may lead to severe left ventricular dysfunction postoperatively and convert the surgical procedure from a potentially curative one to a palliative surgery. In this regard, we have even described a novel technique of plicating the posterior mitral valve leaflet in patients with residual gradient after resection and plication of anterior mitral leaflet.[6] Replacement of mitral valve is reserved only for calcified mitral valve leaflets in patients with residual obstruction after extended septal myectomy. The indices for residual systolic anterior motion described by Varghese et al. pertain to degenerative mitral valve repair and are not validated in HCM patients and should not be used as an indicator for mitral valve replacement in this subset of patients.

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Conflicts of interest

There are no conflicts of interest.

   References Top

Aggarwal N, Khanuja JS, Arora SS, Maria R. Abnormal mitral valve apparatus in a case of hypertrophic obstructive cardiomyopathy: Intraoperative transesophageal echocardiography. Ann Card Anaesth 2018;21:315-8.  Back to cited text no. 1
[PUBMED]  [Full text]  
Sherrid MV, Balaram S, Kim B, Axel L, Swistel DG. The mitral valve in obstructive hypertrophic cardiomyopathy: A test in context. J Am Coll Cardiol 2016;67:1846-58.  Back to cited text no. 2
Varma PK, Neema PK. Hypertrophic cardiomyopathy: Part 1 – Introduction, pathology and pathophysiology. Ann Card Anaesth 2014;17:118-24.  Back to cited text no. 3
[PUBMED]  [Full text]  
Maron MS, Olivotto I, Harrigan C, Appelbaum E, Gibson CM, Lesser JR, et al. Mitral valve abnormalities identified by cardiovascular magnetic resonance represent a primary phenotypic expression of hypertrophic cardiomyopathy. Circulation 2011;124:40-7.  Back to cited text no. 4
Swistel DG, Balaram SK. Surgical myectomy for hypertrophic cardiomyopathy in the 21st century, the evolution of the “RPR” repair: Resection, plication, and release. Prog Cardiovasc Dis 2012;54:498-502.  Back to cited text no. 5
Varma PK, Krishna N, Ahamed H, Madassery S. Posterior mitral leaflet plication for hypertrophic obstructive cardiomyopathy. Asian Cardiovasc Thorac Ann 2018;26:400-3.The Editor,  Back to cited text no. 6

Correspondence Address:
Praveen Kerala Varma
Center for Hypertrophic Cardiomyopathy, Amrita Institute of Medical Sciences and Research Center, Kochi, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aca.ACA_160_18

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