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Ketamine in adult cardiac surgery and the cardiac surgery Intensive Care Unit: An evidence-based clinical review


1 Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
2 Department of Pharmacy, Emory University School of Medicine, Atlanta, Georgia, USA

Correspondence Address:
Dr. Michael Mazzeffi
University of Maryland School of Medicine, 22 South Greene Street S11C00, Baltimore, MD 21201
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9784.154478

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Year : 2015  |  Volume : 18  |  Issue : 2  |  Page : 202-209

 

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Ketamine is a unique anesthetic drug that provides analgesia, hypnosis, and amnesia with minimal respiratory and cardiovascular depression. Because of its sympathomimetic properties it would seem to be an excellent choice for patients with depressed ventricular function in cardiac surgery. However, its use has not gained widespread acceptance in adult cardiac surgery patients, perhaps due to its perceived negative psychotropic effects. Despite this limitation, it is receiving renewed interest in the United States as a sedative and analgesic drug for critically ill-patients. In this manuscript, the authors provide an evidence-based clinical review of ketamine use in cardiac surgery patients for intensive care physicians, cardio-thoracic anesthesiologists, and cardio-thoracic surgeons. All MEDLINE indexed clinical trials performed during the last 20 years in adult cardiac surgery patients were included in the review.






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1 Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
2 Department of Pharmacy, Emory University School of Medicine, Atlanta, Georgia, USA

Correspondence Address:
Dr. Michael Mazzeffi
University of Maryland School of Medicine, 22 South Greene Street S11C00, Baltimore, MD 21201
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9784.154478

Rights and Permissions

Ketamine is a unique anesthetic drug that provides analgesia, hypnosis, and amnesia with minimal respiratory and cardiovascular depression. Because of its sympathomimetic properties it would seem to be an excellent choice for patients with depressed ventricular function in cardiac surgery. However, its use has not gained widespread acceptance in adult cardiac surgery patients, perhaps due to its perceived negative psychotropic effects. Despite this limitation, it is receiving renewed interest in the United States as a sedative and analgesic drug for critically ill-patients. In this manuscript, the authors provide an evidence-based clinical review of ketamine use in cardiac surgery patients for intensive care physicians, cardio-thoracic anesthesiologists, and cardio-thoracic surgeons. All MEDLINE indexed clinical trials performed during the last 20 years in adult cardiac surgery patients were included in the review.






[FULL TEXT] [PDF]*


        
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