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Influence of ethanol-induced pulmonary embolism on hemodynamics in pigs


1 Department of Pathophysiological and Therapeutic Science, Division of Radiology, Tottori University, 36-1 Nishicho, Yonago, Tottori 683-8504, Japan
2 Department of Radiology, Tottori Prefectural Kosei Hospital, 150 Higashishowa-Machi, Kurayoshi, Tottori 682-0804, Japan
3 Department of Radiology, San-in Rosai Hospital, 1-8-1 Kaikeshinden, Yonago, Tottori 683-8605, Japan
4 R and D Center, Terumo Corporation, 1900-1 Inokuchi, Nakaimachi, Ashigarakami-Gun, Kanagawa 259-0151, Japan
5 Department of Microbiology and Pathology, Organ Pathology, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago, Tottori 683-8504, Japan

Correspondence Address:
Shinsaku Yata
Division of Radiology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago, Tottori 683-8504
Japan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9784.119164

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Year : 2013  |  Volume : 16  |  Issue : 4  |  Page : 245-249

 

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Aims and Objectives: Ethanol is widely used for the embolization treatment of vascular malformations, but it can also cause serious complications such us pulmonary hypertension, cardiopulmonary collapse and death. The complications are considered secondary to pulmonary vasospasm and ethanol-induced sludge embolism, etc., We studied the hemodynamic effects of intravenous absolute ethanol injection and ethanol sludge injection in pigs. Materials and Methods: A total of 5 pigs underwent intravenous injection of ex vivo generated ethanol-induced sludge in which residual ethanol was removed (Group S) and 4 pigs underwent intravenous injection of absolute ethanol (Group E). Hemodynamic parameters related to the pulmonary and systemic circulation were compared between the groups. Results: Transient pulmonary hypertension was observed in both groups and the hemodynamic changes were similar in both groups. Conclusions: Sludge can induce transient pulmonary hypertension or cardiopulmonary collapse, without ethanol and may be the mechanism by which ethanol induces its adverse hemodynamic effects.






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1 Department of Pathophysiological and Therapeutic Science, Division of Radiology, Tottori University, 36-1 Nishicho, Yonago, Tottori 683-8504, Japan
2 Department of Radiology, Tottori Prefectural Kosei Hospital, 150 Higashishowa-Machi, Kurayoshi, Tottori 682-0804, Japan
3 Department of Radiology, San-in Rosai Hospital, 1-8-1 Kaikeshinden, Yonago, Tottori 683-8605, Japan
4 R and D Center, Terumo Corporation, 1900-1 Inokuchi, Nakaimachi, Ashigarakami-Gun, Kanagawa 259-0151, Japan
5 Department of Microbiology and Pathology, Organ Pathology, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago, Tottori 683-8504, Japan

Correspondence Address:
Shinsaku Yata
Division of Radiology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago, Tottori 683-8504
Japan
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9784.119164

Rights and Permissions

Aims and Objectives: Ethanol is widely used for the embolization treatment of vascular malformations, but it can also cause serious complications such us pulmonary hypertension, cardiopulmonary collapse and death. The complications are considered secondary to pulmonary vasospasm and ethanol-induced sludge embolism, etc., We studied the hemodynamic effects of intravenous absolute ethanol injection and ethanol sludge injection in pigs. Materials and Methods: A total of 5 pigs underwent intravenous injection of ex vivo generated ethanol-induced sludge in which residual ethanol was removed (Group S) and 4 pigs underwent intravenous injection of absolute ethanol (Group E). Hemodynamic parameters related to the pulmonary and systemic circulation were compared between the groups. Results: Transient pulmonary hypertension was observed in both groups and the hemodynamic changes were similar in both groups. Conclusions: Sludge can induce transient pulmonary hypertension or cardiopulmonary collapse, without ethanol and may be the mechanism by which ethanol induces its adverse hemodynamic effects.






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