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When blood is thinner than water


Department of Internal Medicine, Princess Durru Shehvar Children's and General Hospital, Purani Haveli, Hyderabad, India

Correspondence Address:
Dilip Gude
Department of Internal Medicine, Princess Durru Shehvar Children's and General Hospital, Purani Haveli, Hyderabad
India
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Source of Support: Princess Durru Shehvar Children’s and General Hospital Hyderabad, Andhra Pradesh, India, Conflict of Interest: None


DOI: 10.4103/0971-9784.105375

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Year : 2013  |  Volume : 16  |  Issue : 1  |  Page : 63-65

 

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Antagonists of vitamin K dependant clotting factors are commonly used as treatment/prophylaxis for anticoagulation. Due to their narrow therapeutic window, a wide range of complications including death may occur. International normalized ratio (INR) is monitored to measure adequacy/excess of anticoagulation. There is a plethora of risk factors that may contribute to the uncontrollably high INR values. We describe our experience of a case of deep venous thrombosis wherein the patient had an overshoot of INR during anticoagulation therapy. We review the literature and discuss management in such scenarios.






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Department of Internal Medicine, Princess Durru Shehvar Children's and General Hospital, Purani Haveli, Hyderabad, India

Correspondence Address:
Dilip Gude
Department of Internal Medicine, Princess Durru Shehvar Children's and General Hospital, Purani Haveli, Hyderabad
India
Login to access the Email id

Source of Support: Princess Durru Shehvar Children’s and General Hospital Hyderabad, Andhra Pradesh, India, Conflict of Interest: None


DOI: 10.4103/0971-9784.105375

Rights and Permissions

Antagonists of vitamin K dependant clotting factors are commonly used as treatment/prophylaxis for anticoagulation. Due to their narrow therapeutic window, a wide range of complications including death may occur. International normalized ratio (INR) is monitored to measure adequacy/excess of anticoagulation. There is a plethora of risk factors that may contribute to the uncontrollably high INR values. We describe our experience of a case of deep venous thrombosis wherein the patient had an overshoot of INR during anticoagulation therapy. We review the literature and discuss management in such scenarios.






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