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    Abstract
   Introduction
    Materials and Me...
   Results
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Table of Contents
ORIGINAL ARTICLE  
Year : 2012  |  Volume : 15  |  Issue : 4  |  Page : 274-277
A survey on the use of intra-aortic balloon pump in cardiac surgery


1 Department of Anesthesia and Intensive Care, Universitą Vita-Salute San Raffaele, Milan, Italy
2 Department of Anesthesiology and Intensive Care, La Sapienza University, Rome, Italy
3 Department of Cardiothoracic Anaesthesia and Intensive Care Medicine, University Hospital of Pisa, Pisa, Italy

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Date of Submission18-Jan-2012
Date of Acceptance02-Jun-2012
Date of Web Publication1-Oct-2012
 

   Abstract 

Intra-aortic balloon pump (IABP) is an established tool in the management of cardiac dysfunction in cardiac surgery. The best timing for IABP weaning is unknown and varies greatly among cardiac centers. The authors investigated the differences in IABP management among 66 cardiac surgery centers performing 40,675 cardiac surgery procedures in the 12-month study period. The centers were contacted through email, telephone, or in person interview. IABP management was very heterogeneous in this survey: In 43% centers it was routinely removed on the first postoperative day, and in 34% on the second postoperative day. In 50% centers, it was routinely removed after extubation of the patients whereas in 15% centers it was removed while the patients were sedated and mechanically ventilated. In 66% centers, patients were routinely receiving pharmacological inotropic support at the time of removal of IABP. The practice of decreasing IABP support was also heterogeneous: 57% centers weaned by reducing the ratio of beat assistance whereas 34% centers weaned by reducing balloon volume. We conclude that the management of IABP is heterogeneous and there is a need for large prospective studies on the management of IABP in cardiac surgery.

Keywords: Cardiac surgery, IABP, Intensive care, Intra-aortic balloon pump, Survey

How to cite this article:
Bignami E, Tritapepe L, Pasin L, Meroni R, Corno L, Testa V, Landoni G, Guarracino F, Zangrillo A. A survey on the use of intra-aortic balloon pump in cardiac surgery. Ann Card Anaesth 2012;15:274-7

How to cite this URL:
Bignami E, Tritapepe L, Pasin L, Meroni R, Corno L, Testa V, Landoni G, Guarracino F, Zangrillo A. A survey on the use of intra-aortic balloon pump in cardiac surgery. Ann Card Anaesth [serial online] 2012 [cited 2020 Oct 21];15:274-7. Available from: https://www.annals.in/text.asp?2012/15/4/274/101871



   Introduction Top


High-risk patients undergoing cardiac surgery, especially those with severe coronary artery disease, are at high risk for myocardial ischemia, arrhythmia, and heart failure. Different therapeutic options are available to support the heart in the perioperative period: these include cardiovascular drugs such as inotropes, vasopressors, and vasodilators, devices such as intra-aortic balloon pump (IABP) and ventricular assist devices, or a combination of the above.

IABP increases myocardial oxygen supply by increasing diastolic coronary perfusion pressure, thereby increasing myocardial and subendocardial perfusion, and decreases myocardial oxygen demand by reducing left ventricular afterload. Additionally, IABP can also improve cardiac output (CO), ejection fraction (EF), and systemic perfusion. IABP can be placed before, during, or after surgery with preoperative IABP insertion being associated with lower in-hospital mortality rates in high-risk patients when compared to those who received it postoperatively. [1] IABP usually remains in place for a variable time after surgery which usually ranges from 24 to 72 hours; the duration of IABP support depends on patients' needs and/or local protocols. IABP can be used in combination with inotropes such as epinephrine, dobutamine, norepinephrine, levosimendan, etc.; however, there is no guideline whether to first perform the weaning from the IABP or from the inotropic or circulatory support drugs. [2] At the same time, there is no consensus on the weaning modalities from IABP. The IABP support can be programmed to assist every beat (1:1) or less often (1:2, 1:4, or 1:8) [3] and weaning from IABP can be achieved by reducing the ratio of assisted to non-assisted beats from 1:1 to 1:2 or less. Alternatively, IABP weaning can be achieved by gradually decreasing the balloon volume, thus reducing the circulatory support and myocardial perfusion support during each cardiac cycle. The aim of this national survey was to assess the management of IABP weaning, the combination of its use with drugs, and the rate of complications associated with its use.


   Materials and Methods Top


The authors conducted a survey regarding elective use of IABP during cardiac surgery in 66 Italian cardiac surgery centers. All centers answered a standardized questionnaire [Table 1] through email, or on telephonic interview, or in person. The physician in charge of the intensive care unit (ICU) or one of his colleagues was contacted. In Italy, anesthesiologists and intensive care specialists have the same curriculum and skills and they work in operating rooms and in ICUs. The survey was therefore answered by anesthesiologists and intensive care specialists. In less than half of the hospitals, the postoperative ICU management of patients undergoing cardiac surgery is performed by cardiac surgeons and in these cases the questionnaire was, in part, answered by cardiac surgeons. IABP positioning was usually performed by cardiac surgeons in the operating rooms and by anesthesiologists/intensive care specialists in the ICU. IABP removal was usually performed by anesthesiologists/intensive care specialists. Surgical positioning and removal of IABP was rare, and if required, performed by surgeons. The above-described practice is also the standard management at our center. Data are expressed as numbers and percentages.
Table 1: Questionnaire on the use of IABP administered to 66 Italian medical centers

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   Results Top


All 66 medical centers answered to the questionnaire. Overall, 40,675 cardiac surgeries were performed in the 12-month study period (mean: 616 per center) with an average of 31 IABP positioned per year per center. No IABP-related complication was reported in 52% of centers. The IABP-related complications reported by the remaining centers are listed in [Table 2]. The patient with the acute thrombosis of the abdominal aorta died and this was the only IABP-related fatal complication.
Table 2: Major complications related to IABP in a 12-month period in 66 centers

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IABP was routinely removed on the first (43%) or second (34%) postoperative day while 23% of centers did not have fixed rules. All centers underlined that patients' clinical condition, hemodynamic status, and echocardiography data were carefully evaluated before removing IABP. Half of the centers performed weaning from IABP support when the patient was awake and extubated, 15% during patient sedation, and 15% when the patient was awake but intubated. Many centers (20%) did not have a single strategy and considered the clinical condition of each patient, and the comorbidities to choose the best strategy. IABP was removed before weaning from inotropic support in 51% centers and after weaning from inotropes in 46% centers, with few centers (3%) having multiple strategies. IABP was always used together with pharmacological inotropic support in the majority of centers (66%) while 39% of centers used one of the following agents only if clinically required: dobutamine, dopamine, epinephrine, norepinephrine, enoximone, and levosimendan. Weaning from IABP was performed in 57% centers by reducing the ratio of beat-to-beat assistance from 1:1 to 1:2 to 1:4, in other 34% centers by reducing IABP balloon volume, and two other centers using the two techniques simultaneously, one center turning the IABP off abruptly and two centers using modified techniques.


   Discussion Top


The results of this survey confirm that the management of IABP removal is heterogeneous among centers. Apparently, in the absence of evidence-based medicine, decisions are taken by the intensive care physicians on the basis of tradition, physiological hypothesis, or personal opinions. Different management strategies could be equivalent or one could be superior to the other one. It is unknown whether different modalities of IABP weaning (reducing the ratio of beat assistance or reducing the balloon volume) are equivalent in terms of clinically significant outcomes. Similarly, it is unknown whether removing the IABP on the first or on the second postoperative day in patients with an uneventful postoperative course could either decrease costs and infections (if the correct approach is to remove it early) or decrease the risks of low CO and organ failure (if the right approach is to remove it later).

Similarly, removing the IABP with the patient sedated and intubated could reduce pain and stress or, conversely, not allow the patient to have the IABP support during extubation, probably the most stressful postoperative period. Should all patients with IABP receive inotropic agents (with all the positive and detrimental effects of these drugs)? Should we consider all inotropic agents harmful when meta-analyses of randomized trials suggested that in the specific setting of cardiac surgery these drugs potentially reduce or increase perioperative mortality? [4],[5] An intriguing aspect that has only recently come to the attention of the medical community is that, at least in selected patients, IABP could be substituted by new inotropes. [6]

Although the incidence of complications associated with the use of IABP has decreased significantly, IABP still holds a risk for complications. The most common vascular complication is limb ischemia. It may occur in 14-45% of patients receiving IABP therapy. If signs of ischemia appear, the balloon should be removed. Other complications associated with IABP are arterial injury (dissection or perforation), peripheral embolization, femoral artery thrombosis, infection, and bleeding. Additionally, the balloon can break into the bloodstream resulting in gas embolization. [7] Complication rate was low in this survey with only one fatal complication occurring. The new devices and techniques of insertion have rendered this technique safe. Further, due to improvement in technology and use of new materials, IABP nowadays plays a very important role in the management of ischemic and dysfunctional myocardium. [7]

A recent consensus conference identified IABP support among the few techniques/strategies capable of reducing perioperative mortality in the setting of cardiac surgery. [8] In fact, a recent meta-analysis of randomized controlled trials suggested that preoperative IABP can reduce mortality in high-risk CABG patients. [1]


   Conclusions Top


The IABP support was used in more than 1800 patients in 66 centers including 40,675 cardiac surgery procedures performed in 1 year. The IABP management was very heterogeneous in this survey. The weaning from IABP support consisted of reducing the ratio of beat-to-beat assistance or reduction in balloon volume. The IABP support was removed either on the first or second postoperative day, in awake and extubated patients or in sedated and mechanically ventilated patients; the patients were either weaned from or receiving inotropic support. Since IABP management can either improve patients' outcome or unnecessarily prolong ICU stay and iatrogenic complication, this topic should be further evaluated in prospective studies.


   Acknowledgment Top


We are indebted to Zuppelli Paola for the help in data entry.

 
   References Top

1.Theologou T, Bashir M, Rengarajan A, Khan O, Spyt T, Richens D, et al. Preoperative intra aortic balloon pumps in patients undergoing coronary artery bypass grafting. Cochrane Database Syst Rev 2011;1:CD004472.  Back to cited text no. 1
[PUBMED]    
2.Bastien O, Vallet B; French Study Group AGIR. French multicentre survey on the use of inotropes after cardiac surgery. Crit Care 2005;9:241-2.  Back to cited text no. 2
[PUBMED]    
3.Krishna M, Zacharowski K. Principles of intra-aortic balloon pump counterpulsation. Cont Edu Anaesth Crit Care Pain 2009;9:24-8.  Back to cited text no. 3
    
4.Landoni G, Biondi-Zoccai G, Greco M, Greco T, Bignami E, Morelli A, et al. Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies. Crit Care Med 2012;40:634-46.  Back to cited text no. 4
[PUBMED]    
5.Zangrillo A, Biondi-Zoccai G, Ponschab M, Greco M, Corno L, Covello RD, et al. Milrinone and mortality in adult cardiac surgery: A meta-analysis. J Cardiothorac Vasc Anesth 2012;26:70-7.  Back to cited text no. 5
[PUBMED]    
6.Severi L, Lappa A, Landoni G, Di Pirro L, Luzzi SJ, Caravetta P, et al. Levosimendan versus intra-aortic balloon pump in high-risk cardiac surgery patients. J Cardiothorac Vasc Anesth 2011;25:632-6.  Back to cited text no. 6
[PUBMED]    
7.Overwalder PJ. Intra-Aortic Balloon Pump (IABP). Counterpulsation. Internet J Thorac Cardiovasc Surg 1999;2.  Back to cited text no. 7
    
8.Landoni G, Rodseth R, Santini F, Ponshab M, Ruggeri L, Szekely A, et al. Randomized evidence for reduction in perioperative mortality.J Cardiothorac Vasc Anesth 2012;26:764-72.  Back to cited text no. 8
    

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Correspondence Address:
Giovanni Landoni
Department of Cardiothoracic Anesthesia and Intensive Care, San Raffaele Hospital, Via Olgettina 60 Milan 20132
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9784.101871

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    Tables

  [Table 1], [Table 2]

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