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Figure 4: Funnel plots for each individual outcome: (a) All-cause mortality; table (b) favorable neurological outcomes. Randomized controlled trials are shown as open circles and the observed summary point estimate in log units is shown as an open diamond. The imputed studies are shown as a filled circle, and the imputed point estimate in log units is shown as a filled diamond, No imputed studies were seen for overall mortality. Two imputed studies were seen for favorable neurological outcomes. Under the random effect model the point estimate and 95% confidence interval for the combined studies is 0.78 (0.73, 0.83). Using trim and fill, the imputed point estimate is 0.77 (0.72, 0.82)

Figure 4: Funnel plots for each individual outcome: (a) All-cause mortality; table (b) favorable neurological outcomes. Randomized controlled trials are shown as open circles and the observed summary point estimate in log units is shown as an open diamond. The imputed studies are shown as a filled circle, and the imputed point estimate in log units is shown as a filled diamond, No imputed studies were seen for overall mortality. Two imputed studies were seen for favorable neurological outcomes. Under the random effect model the point estimate and 95% confidence interval for the combined studies is 0.78 (0.73, 0.83). Using trim and fill, the imputed point estimate is 0.77 (0.72, 0.82)