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Figure 2: Mechanism of action of bosentan. (ET-1 = endothelin; SMC = smooth muscle cell; EC = endothelial cell; ETA = endothelin receptor A; and ETB = endothelin receptor B).

Figure 2: Mechanism of action of bosentan. (ET-1 = endothelin; SMC = smooth muscle cell; EC = endothelial cell; ETA = endothelin receptor A; and ETB = endothelin receptor B).