Year : 2020  |  Volume : 23  |  Issue : 1  |  Page : 20--26

Role of central venous - Arterial pCO2 difference in determining microcirculatory hypoperfusion in off-pump coronary artery bypass grafting surgery


Hitendra Kanzariya1, Jigisha Pujara1, Sunny Keswani1, Karan Kaushik1, Vivek Kaul1, R Ronakh1, Himani Pandya2 
1 Department of Cardiac Anesthesia, U. N. Mehta Institute of Cardiology and Research Center, Ahmadabad, Gujarat, India
2 Department of Research, U. N. Mehta Institute of Cardiology and Research Center, Ahmadabad, Gujarat, India

Correspondence Address:
Jigisha Pujara
Department of Cardiac Anesthesia, U. N. Mehta Institute of Cardiology and Research Centre, Civil Hospital Campus, Asarva, Ahmedabad - 380 016, Gujarat
India

Background: Cardiac surgery is frequently associated with macro and microcirculatory hypoperfusion. Patients with normal central venous oxygen saturation (Scvo2) also suffer from hypoperfusion. We hypothesized that monitoring central venous-arterial pco2 difference (dCO2) could also serve as additional marker in detecting hypoperfusion in cardiac surgery patient. Methods: This is a prospective observational study. Patients undergoing off-pump coronary artery bypass grafting included in this study. The dCO2 was measured postoperatively. The patients with a ScvO2 ≥70% were divided in to 2 groups, the high-dCO2 group (≥8 mmHg) and the low-dCO2 group (<8 mmHg). Results: The 65 patient had scvO2 ≥70%. Out of these, 20 patients were assigned to the high dCO2 group and 45 patients to the low dCO2 group. Patients with high dco2 had higher lactate levels after ICU admission. They also had significantly prolonged need for mechanical ventilation (14.90 ± 10.33 vs 10 ± 9.65, P = 0.0402), ICU stay (5.05 ± 2.52 d vs 3.75 ± 2.36 d, P = 0.049) and hospital stay (12.25 ± 5.90 d vs 8.57 ± 5.55 d P = 0.018). The overall rate of post-operative complications was similar in both the group. Conclusion: The present study demonstrates dCO2 as an easy to assess and routinely available tool to detect global and microcirculatory hypoperfusion in off-pump CABG patients, with assumed adequate fluid status and ScvO2 as a hemodynamic goal. We observed that high dCO2 (>8 mmHg) was associated with decreased DO2I, increased oxygen extraction ratio, the longer need for mechanical ventilation and longer ICU stay.


How to cite this article:
Kanzariya H, Pujara J, Keswani S, Kaushik K, Kaul V, Ronakh R, Pandya H. Role of central venous - Arterial pCO2 difference in determining microcirculatory hypoperfusion in off-pump coronary artery bypass grafting surgery.Ann Card Anaesth 2020;23:20-26


How to cite this URL:
Kanzariya H, Pujara J, Keswani S, Kaushik K, Kaul V, Ronakh R, Pandya H. Role of central venous - Arterial pCO2 difference in determining microcirculatory hypoperfusion in off-pump coronary artery bypass grafting surgery. Ann Card Anaesth [serial online] 2020 [cited 2020 Feb 23 ];23:20-26
Available from: http://www.annals.in/article.asp?issn=0971-9784;year=2020;volume=23;issue=1;spage=20;epage=26;aulast=Kanzariya;type=0