Year : 2012  |  Volume : 15  |  Issue : 1  |  Page : 18--25

The effects of preemptive pregabalin on attenuation of stress response to endotracheal intubation and opioid- sparing effect in patients undergoing off-pump coronary artery bypass grafting


Ayya Syama Sundar1, Rajeshkumar Kodali1, Sajith Sulaiman1, Harish Ravullapalli1, Ranjith Karthekeyan1, Mahesh Vakamudi2 
1 Department of Cardiac Anaesthesiology, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, India
2 Department of Anaesthesiology and Critical Care, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, India

Correspondence Address:
Ranjith Karthekeyan
Department of Cardiac Anaesthesiology, Sri Ramachandra Medical College and Research Institute, No. 1, Ramachandra Nagar, Porur, Chennai 116
India

The clinical study was designed to evaluate and compare single preoperative dose of pregabalin to a placebo regarding hemodynamic responses to laryngoscopy and endotracheal intubation, to assess perioperative fentanyl requirement and any side-effects. It was a randomized, double-blind, placebo-controlled, parallel assignment, efficacy study. The study was done at a tertiary university hospital. This study was a comparison between two groups of 30 adult patients scheduled for elective off pump coronary artery bypass surgery. In the control group, the patients were given placebo capsules, and in the pregabalin group, the patients were given pregabalin 150 mg capsule orally 1 h before surgery. The patients were compared for hemodynamic changes before the start of the surgery, after induction, 1, 3, and 5 min after intubation. Additionally, fentanyl requirement during surgery and the first postoperative day was also compared. The present study shows that a single oral dose of 150 mg pregabalin given 1 h before surgery attenuated the pressor response to tracheal intubation in adults, but the drug did not show any effect on perioperative opioid consumption and was devoid of side-effects in the given dose.


How to cite this article:
Sundar AS, Kodali R, Sulaiman S, Ravullapalli H, Karthekeyan R, Vakamudi M. The effects of preemptive pregabalin on attenuation of stress response to endotracheal intubation and opioid- sparing effect in patients undergoing off-pump coronary artery bypass grafting.Ann Card Anaesth 2012;15:18-25


How to cite this URL:
Sundar AS, Kodali R, Sulaiman S, Ravullapalli H, Karthekeyan R, Vakamudi M. The effects of preemptive pregabalin on attenuation of stress response to endotracheal intubation and opioid- sparing effect in patients undergoing off-pump coronary artery bypass grafting. Ann Card Anaesth [serial online] 2012 [cited 2019 Oct 13 ];15:18-25
Available from: http://www.annals.in/article.asp?issn=0971-9784;year=2012;volume=15;issue=1;spage=18;epage=25;aulast=Sundar;type=0