| Abstract|| |
Cardiac surgery induces severe postoperative pain and impairment of pulmonary function, increases the length of stay (LOS) in hospital, and increases mortality and morbidity; therefore, evaluation of the evidence is needed to assess the comparative benefits of different techniques of pain management, to guide clinical practice, and to identify areas of further research. A systematic search of the Cochrane Central Register of Controlled Trials, DARE database, Joanna Briggs Institute, Google scholar, PUBMED, MEDLINE, EMBASE, Academic OneFile, SCOPUS, and Academic search premier was conducted retrieving 1875 articles. This was for pain management postcardiac surgery in intensive care. Four hundred and seventy-one article titles and 266 abstracts screened, 52 full text articles retrieved for critical appraisal, and ten studies were included including 511 patients. Postoperative pain (patient reported), complications, and LOS in intensive care and the hospital were evaluated. Anesthetic infiltrations and intercostal or parasternal blocks are recommended the immediate postoperative period (4–6 h), and patient-controlled analgesia (PCA) and local subcutaneous anesthetic infusions are recommended immediate postoperative and 24–72 h postcardiac surgery. However, the use of mixed techniques, that is, PCA with opioids and local anesthetic subcutaneous infusions might be the way to go in pain management postcardiac surgery to avoid oversedation and severe nausea and vomiting from the narcotics. Adequate studies in the use of ketamine for pain management postcardiac surgery need to be done and it should be used cautiously.
Keywords: “Pain” management, pain guidelines, cardiac surgery, cardiothoracic intensive care, critical care, intensive care unit, local anesthetic subcutaneous infusions, meta-analyses, open heart surgery, pain, pain busters, pain protocols, paravertebral blocks, patient-controlled analgesia, postcardiac surgery, randomized controlled trials, sternotomy
|How to cite this article:|
Nachiyunde B, Lam L. The efficacy of different modes of analgesia in postoperative pain management and early mobilization in postoperative cardiac surgical patients: A systematic review. Ann Card Anaesth 2018;21:363-70
|How to cite this URL:|
Nachiyunde B, Lam L. The efficacy of different modes of analgesia in postoperative pain management and early mobilization in postoperative cardiac surgical patients: A systematic review. Ann Card Anaesth [serial online] 2018 [cited 2019 May 25];21:363-70. Available from: http://www.annals.in/text.asp?2018/21/4/363/243528
| Introduction|| |
Pain is known to be an unpleasant sensory and emotional experience associated with potential and actual tissue damage. Despite major advances of postoperative pain management, it continues to be a significant problem for many patients after major surgery. Sternotomy, rib retraction, conduit harvest, and drain tubes are some of the sources of pain in cardiac surgery. Therefore, postcardiothoracic surgery, the role of planned pain management is crucial for early mobilization, decreasing pulmonary complications such as atelectasis, shortening the hospital length of stay (LOS), and reducing cardiovascular and endocrine complications.
Regional anesthetic infiltrations and subcutaneous infusions (pain busters) around the wound are some of the pain management techniques which carry the advantages of providing superior analgesia and avoiding some of the adverse effects of systemic opioid treatment. However, opioid infusions and patient-controlled analgesia (PCA) remain the primary and most commonly used pharmacological therapies immediate postoperative after cardiac surgery in Intensive Care Units (ICUs).
Epidural analgesia or blocks for pain management will not be considered in this review because of the controversy and contraindication that surrounds its use in cardiac patients including complications such as hematoma due to perioperative coagulation. Mazzeffi and Khelemsky stated that, “even if the risk of developing a hematoma in cardiac surgery is known to be 1 in 12000, due to the severity of the consequences related to epidural hematomas, this technique remains underused in postoperative pain management in cardiac surgery.”
The efficacy of ketamine and opioid infusions, paravertebral blocks, PCA, subcutaneous nurse-administered opioids, ropivacaine/bupivacaine local continuous subcutaneous infusions, and infiltrations in cardiac surgery have been assessed in this review of randomized controlled trials. This is in relation to postoperative pain management, early mobilization, and LOS in intensive care and hospital in general.
| Materials and Methods|| |
Inclusion and exclusion
Included were randomized controlled trial articles for adults eighteen years and over post cardiac surgery. These included the use of subcutaneous anesthetic infusions, paravertebral blocks/infiltrations, PCAs, Ketamine/ opioid infusions and nurse administered subcutaneous (NASC) opioids for pain management in Intensive care. There was no restriction to opioids or anesthetic medications used were made. Included studies were all postcardiac surgery articles, including valve repair or replacement and coronary artery bypass and grafts in intensive care.
All studies using epidural analgesia or blocks for pain management postcardiac surgery were excluded from the study.
Two independent reviewers searched the Cochrane Central Register of controlled trials, Joanna Briggs Institute and the Google scholar. EMBASE, DARE, PUBMED, MEDLINE and SCOPUS databases were also searched using the keywords above.
Critical appraisal tools
The JBI critical appraisal form for randomized controlled trials was used. Eligible studies were graded using the following scoring system:First, if there was true randomization used for assignment of participants to the treatment groups, if the allocation was concealed, and if the outcome assessors were blind to the assignment. The description of an appropriate method of double blinding was graded as follows: yes, no, and unclear. The studies had to have a YES on criteria 1, 2, and 6 to qualify. The flow diagram is included below and shows how the search strategy was done and articles included and excluded.
The JBI data extraction form was used as a model for data extraction but was modified to the specific need of information for this specific systematic review. Any data on patient-reported pain using visual analog scale (VAS) and numerical rating scores were extracted from the studies. Specific outcomes that were extracted included pain scores at rest and with activity including coughing and need for rescue medication. The complications as described in the outcome measures were indicated where applicable. Data on LOS in ICU and in hospital were extracted where recorded.
Analysis of outcomes
Information from each included study was recorded in data tables [Table 1]. The primary outcomes were patient-reported pain, LOS, and complications due to inadequate pain management (atelectasis, pneumonia, wound infection, and increase in mortality/morbidity) where reported. Means and standard deviations (SDs) were extracted from the text, tables, or graphs within the studies. Quantitative analysis was limited by heterogeneity in study designs, and the subject numbers were small. The limited number of randomized controlled studies led to a narrative synthesis of the systematic review.
| Results|| |
Database searches yielded 1875 articles. Further screening yielded 873 articles in which inclusion and exclusion titles and abstracts reduced the number of articles to 52; 52 were retrieved, 13 of which were noncardiac articles, 4 were reviews, 8 were cardiac but nonrandomized controlled trials, and 17 articles failed to meet the criteria during data extraction. Ten articles were included in this study. Randomized clinical trials enrolling a total of 511 patients were included for the final narrative analysis [Figure 1]. Flow diagram for pain management postcardiac surgery shows the search criteria.
|Figure 1: Pain management post cardiac surgery. Flowchart describing the search criteria|
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Local infiltrations and parasternal blocks
Parasternal block and local anesthetic infiltrations with levobupivacaine versus Saline (P) showed significantly less use of morphine as a rescue drug in the levobupivacaine (LB) group (P = 0.02) compared to the P group after surgery over the 24 h period. Zero percentage of the LB group needed rescue medication versus 44.4% of the P group. The VAS scores were not significantly different at rest and when coughing, statistically as indicated in [Figure 2]a and [Figure 2]b below. Alveolar-arterial oxygen gradient and partial oxygen were measured and were significantly better in the LB group at the time of extubation and better throughout the first 24 h period.
|Figure 2: Verbal analog scores for pain at rest (a) and with cough (b) on a standard 0 to 10 scale over the first 24 h after surgery. Values are a mean ± standard deviation. (McDonald et al. 2005)|
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Parasternal intercostal block with ropivacaine for pain management after cardiac surgery, was used in a double blind randomized controlled trial with saline. The ropivacaine group had almost 50% visual analogue pain scores less than those in the saline group with a mean of 29.5, SD = 24.3 versus 53.2 = 24.1, ropivacaine versus saline respectively, P = 0.001. Numerical rating scale scores were similarly significantly less for patients in the ropivacaine group at extubation with a mean = 2.7 (SD = 1.6) versus 5.2 (SD = 2.0), respectively; (95% CI: −3.3 to −1.7, P = 0.01). The use of morphine PCA in the ropivacaine patients was approximately 50% less for the first 12 h after surgery (12.0 [SD = 5.4] vs. 23.2 [SD = 8.3] total morphine equivalent in milligrams R vs. S respectively; P < 0.001 [95% CI, −14.3 to −8.1]) as indicated in the graph [Figure 3].
|Figure 3: Consumption of patient-controlled analgesia Morphine in the 12 h period (Barr et al.)|
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The Efficacy of parasternal injection of bupivacaine on postoperative pain for early extubation in patients undergoing coronary artery bypass surgery was assessed. The VAS pain score in the bupivacaine group remained 0–3 with a mean (1.38 ± 1.19) and none of the patients required rescue pain medication, while in the placebo group, the mean of 6.13 ± 2.92 which was very significant, the difference in the mean VAS between the two groups (P = 0.001), rescue medication was required in 8 (53.3%) whereas non from Bupivacaine.
Partial oxygen (PaO2) showed a trend to be higher in the Bupivacaine group with a mean of 208.23 ± 42.57, whereas in the placebo, a mean was 126.40 ± 23.15. These results reflected the respiratory comfort and ease of vital capacity whose difference was statistically significant (P < 0.001).
Local subcutaneous infusions
Results of a randomized double blind clinical trial of ropivacaine (0.2%) versus saline showed improved pain control after cardiac surgery. Patients in the ropivacaine group reported significantly less pain than the saline group with a mean overall VAS pain score significantly lower than the saline group (1.6 vs. 2.6, P = 0.005). This also reflected in the total narcotic use where ropivacaine versus the control group 47.3 versus 78.7 mg (P = 0.038), respectively, and day 2 postoperatively (15.5 vs. 29.4 mg, P = 0.025). The mean LOS for the patients in the ropivacaine group was 5.2± (1.3) days, with a range of 3–7 days, whereas the mean LOS in the control group was 8.2 ± 7.9 days with a range of 4–39 days. There was a trend toward improvement in pulmonary function in the ropivacaine group.
The analgesic effects of a bilateral sternal infusion of ropivacaine after cardiac surgery in the first 48 hours proved lower pain scores in the ropivacaine group during mobilization (P = 0.0004) and at rest (P = 0.0006), and the analgesic effects were mostly apparent on day 2 postsurgery. The amount of morphine consumption reduced in the ropivacaine group and their satisfaction and rehabilitation improved; however, no effects were noted on respiratory outcomes. Clinical tolerance and comfort were also better in the ropivacaine group. The ropivacaine plasma levels remained beneath the mean level observed for occurrence of neurologic symptoms.
Local infusion of bupivacaine combined with patient controlled analgesia provides better pain relief than intravenous patient controlled analgesia alone in patients undergoing a minimally invasive cardiac surgery. In this study, there were no differences in time to extubation, ICU, or hospital stay. There appeared to be a trend in reduction in PCA requirements when bupivacaine was infused into the wound. The Sham infusion group had greater and more persistent pain than the bupivacaine infusion group even at 24 h, 48 h, and at 3 months after the operation [Table 2].
The analgesic efficacy of continuous paesternal bupivacaine infusion through a single catheter after cardiac surgery proved to reduce pain scores in the bupivacaine group. The overall morphine requirements over the first 48 h in ICU were significantly less in group B than group C, mean = 8.6 mg ± (0.94) vs. 18.83 mg ± (3.4), respectively, P = 0.02. The mean VAS scores were also significantly less in Group B than Group C at most time points.
The time to extubation was shorter in Group B compared to Group C, with a mean of 117 min (±10) versus 195 min ± (19), respectively, P = 0.03. However, there was no statistical difference between the two groups in the ICU and hospital stay duration. The respiratory parameters such as PaO2/FiO2 and partial carbon-dioxide were better in Group B at extubation, 6 h, 12 h, and 24 h mark compared to Group C [Table 3].
|Table 3: Demonstrates the patient demographics employed by the included studies, the comparisons used and the recorded and reported outcomes|
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S (+) ketamine versus a placebo as an analgesic adjunct proved to reduce opioid consumption after cardiac surgery. During the first 48h postoperatively, the consumption of oxycodone in the S (+) ketamine group was less, mean = 103 mg ± (44) compared to mean of 125 mg ± (45) in the placebo group: mean difference was 22 mg and 95% confidence interval (CI) for the difference of 3–40 mg, P = 0.023. The time after tracheal extubation to the first dose of oxycodone with PCA was longer in the S (+) Ketamine group 134 min ± (125) and 101 min ± (197) respectively, P = 0.013. The VAS pain scores during the 48 h period were comparable both at rest and during a deep breath with no statistical difference. When asked if they could use the same type of analgesia, 41 (93%) of the 44 patients in the S (+) Ketamine group and 41 (89%) of the 46 in the placebo group replied affirmatively.
Pulmonary function tests, mobilization tests, walking exercises with physiotherapists, maximal oxygen capacity (VO2) and Vco2, and postoperative PCO2 levels were higher in the placebo group than the in the S (+) Ketamine group (P = 0.021).
Patient-controlled analgesia and opioids
Patient controlled analgesia of remifentanil(RM) versus morphine (M) post cardiac surgery, did not show a significant difference in effectiveness. After 24 h of PCA use, no statistically significant difference in both groups in pain management. The LOS of the patients in ICU was 46.83± (4.6) h for remifentanil (RM) group and 45.44± (5.6) h for M group. The overall LOS in hospital after the operation was 5.2± (1) days versus 5.1± (1) days, respectively. Each group had 14% of the patients present with atelectasis postoperatively which was treated with chest physiotherapy. However, the overall effectiveness was rated very good or good in 87% by RM group compared to 72% of the patients in the M group.
Nurse administered subcutaneous morphine is a satisfactory alternative to intravenous patient controlled analgesia of morphine after cardiac surgery. There was no statistically significant difference found between the two groups in any of the variables measured. Median VAS pain scores at rest and with movement; on day 1, it was 0 and 3 in the NASC and 0 and 2.5 in the intravenous (IV) PCA, and on day 2, it was 0 and 2.5 in NASC group and 0 and 2 in the IV PCA group. Unblind physiotherapists scored the success of mobilization and the difficulty the patients had in obtaining additional analgesia before physiotherapy for the two groups. For the IV PCA group (VAS scale 1–10), it was 8 (6–9) and 7 (7–8) for the NASC group. Total morphine administered postoperatively was 42.7 ± 32.4 mg in the IV PCA group and 53.3 ± 29.3 mg in the NASC group. Morphine consumption through IV PCA or NASC in the first 24 h after extubation was 33 ± 22 mg and 37 ± 20 mg in the IV PCA group and NASC group, respectively.
| Discussion|| |
Use of opioids analgesics alone postcardiac surgery is an acceptable and established way of pain management worldwide. We performed a systematic review of randomized controlled trials and found that parasternal and intercostal blocks, local anesthetic infiltrations, and local anesthetic continuous infusions when used with background of opioid PCA appeared to be effective pain management in patients postcardiac surgery and improved patient outcomes.
Application of anesthetics directly to wounds provides analgesia by blocking transmission of pain from nociceptive afferents in the wound surface and by inhibiting local inflammatory response to injury, thereby reducing the release of inflammatory mediators from neutrophils and decreasing edema formation.
Infiltrations and parasternal blocks and continuous subcutaneous anesthetic infusions
The local infiltrations and parasternal blocks,, appeared to be much more effective in the first 4–6 up to 24 h postoperatively. This result is in line with previous systematic reviews conducted on evaluating regional techniques for postthoracotomy analgesia. Previous systematic reviews were not able to detect the appreciable benefit from single injection of local anesthetics in abdominal operation or laparoscopy.,
The continuous subcutaneous anesthetic infusions,,, were effective much longer and associated with reduced LOS as indicated in previous review.
In the local anesthetic groups, whether infiltrated, nerve block, or subcutaneous infusions, all patients in the control and treatment groups used opioids to cover other discomforts associated with the operation and ICU admission. The use of both local anesthetic infusions with PCA demonstrated superior analgesia to PCA alone in reducing pain post minimally invasive cardiac surgery. This was also demonstrated in other studies,,,, and led to the reduction in the use of opioids and consequent reductions in hospital stay. Nasr et al. also demonstrated early extubation in the bupivacaine group with better respiratory parameters as indicated by the arterial blood gases (ABG) analyses at the time of extubation and the subsequent readings compared to the control group. On the contrary, Eljezi et al. did not demonstrate any improvement in the respiratory function with improvement in analgesia in their study group. This could have been due to the use of different parameters of assessing respiratory functions, for example, ABGs versus pulmonary function tests. This review also demonstrates why it is important to consider the dosages of the local anesthetics being used to avoid toxicity leading to neurological and cardiac complications.
Opioid administration and patient-controlled analgesia
Administration of opioids is considered a cornerstone of postoperative pain management; greater analgesic efficacy and higher patient satisfaction are achieved with opioid PCA. PCA not only improves patient comfort but also it improves resource utilization. Baltali demonstrated that RM PCA was a better analgesic on the basis of pain scores during coughing and movement. Gurbet et al. in a study, where they compared fentanyl, morphine, and RM, found that PCA of RM provided equal and adequate pain relief at rest after cardiac surgery such as morphine and fentanyl. Munro et al. did not show significance difference in the use of PCA and NASC morphine. In a meta-analysis comparing PCA with nurse-controlled analgesia, there was a 25% reduction in VAS scores for patients who used PCA compared to nurse-controlled analgesia between 24 and 48 h postoperatively.
Ketamine has been used successfully for pain management in various trials.,,, Lahtinen et al. used S (+) ketamine as an analgesic adjunct and proved that it reduced opioid consumption in patients' postcardiac surgery. Epidural S (+) ketamine was used effectively to reduce pain postknee arthroplasty when it was applied with ropivacaine in epidural anesthesia; S (+) Ketamine was given as an infusion post knee arthroscopy, and neither enhanced analgesia, nor provided opioid sparing effect. In Lahtinen et al., four patients developed transient hallucinations during the infusion versus none in the placebo group; however, opioid consumption in the S (+) Ketamine group decreased in the first 48 h.
Limitations to this study
Methodological quality of the randomized controlled trials in this systematic review varied. Due to the strict inclusion and exclusion criteria, the number of studies and ultimately patients for analysis was limited. Not all studies reported on all the outcome measures of interest to this study like complications, LOS. Despite these challenges, the information extracted was in line with previous studies, and the recommendations may lead to new and better ways of pain management in patients postcardiac surgery.
| Conclusion|| |
The use of PCA with opioids in conjunction with local subcutaneous anesthetic continuous infusions is much more effective longer. This approach might eventually be the cornerstone for pain management postcardiac surgery in ICUs. There is a need, therefore, for anesthetists and acute pain service teams to consider the use of mixed methods in pain management postcardiac surgery. There is a need to be cautious with Ketamine use postcardiac surgery until more dose-related studies are done and concerns pertaining to psychotomimetic adverse reactions are addressed.
The authors would like to thank Tiffany Conroy Lecturer at Adelaide University for her expertise in database literature search and blinded critical appraisal.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Magnano D, Montalbano R, Lamarra M, Ferri F, Lorini L, Clarizia S, et al.
Ineffectiveness of local wound anesthesia to reduce postoperative pain after median sternotomy. J Card Surg 2005;20:314-8.
Manion SC, Brennan TJ. Thoracic epidural analgesia and acute pain management. Anesthesiology 2011;115:181-8.
Konstantatos A, Silvers AJ, Myles PS. Analgesia best practice after cardiac surgery. Anesthesiol Clin 2008;26:591-602.
Behera BK, Puri GD, Ghai B. Patient-controlled epidural analgesia with fentanyl and bupivacaine provides better analgesia than intravenous morphine patient-controlled analgesia for early thoracotomy pain. J Postgrad Med 2008;54:86-90.
] [Full text]
Werawatganon T, Charuluxanun S. Patient controlled intravenous opioid analgesia versus continuous epidural analgesia for pain after intra-abdominal surgery. Cochrane Database Syst Rev 2005;(1):CD004088.
Harle CC, Ganapathy S. Paravertebral analgesia for cardiac surgery. Tech Reg Anesth Pain Manag 2008;12:57-63.
Mazzeffi M, Khelemsky Y. Poststernotomy pain: A clinical review. J Cardiothorac Vasc Anesth 2011;25:1163-78.
Chaney MA. Cardiac surgery and intrathecal/epidural techniques: At the crossroads? Can J Anaesth 2005;52:783-8.
McDonald SB, Jacobsohn E, Kopacz DJ, Desphande S, Helman JD, Salinas F, et al.
Parasternal block and local anesthetic infiltration with levobupivacaine after cardiac surgery with desflurane: The effect on postoperative pain, pulmonary function, and tracheal extubation times. Anesth Analg 2005;100:25-32.
Barr AM, Tutungi E, Almeida AA. Parasternal intercostal block with ropivacaine for pain management after cardiac surgery: A double-blind, randomized, controlled trial. J Cardiothorac Vasc Anesth 2007;21:547-53.
Rahman SU, Siddiqi TA, Husain A, Yaseen R, Tanveer R, Badar S, et al
. Efficacy of parasternal injection of Bupivacaine on Post-operative pain for early extubation in patients undergoing coronary artery bypass surgery. J Cardiol Curr Res 2016;6:00210.
Dowling R, Thielmeier K, Ghaly A, Barber D, Boice T, Dine A, et al.
Improved pain control after cardiac surgery: Results of a randomized, double-blind, clinical trial. J Thorac Cardiovasc Surg 2003;126:1271-8.
Eljezi V, Dualé C, Azarnoush K, Skrzypczak Y, Sautou V, Pereira B, et al.
The analgesic effects of a bilateral sternal infusion of ropivacaine after cardiac surgery. Reg Anesth Pain Med 2012;37:166-74.
Chiu KM, Wu CC, Wang MJ, Lu CW, Shieh JS, Lin TY, et al.
Local infusion of bupivacaine combined with intravenous patient-controlled analgesia provides better pain relief than intravenous patient-controlled analgesia alone in patients undergoing minimally invasive cardiac surgery. J Thorac Cardiovasc Surg 2008;135:1348-52.
Nasr DA, Abdelhamid HM, Mohsen M, Aly AH. The analgesic efficacy of continuous presternal bupivacaine infusion through a single catheter after cardiac surgery. Ann Card Anaesth 2015;18:15-20.
] [Full text]
Lahtinen P, Kokki H, Hakala T, Hynynen M. S(+)-ketamine as an analgesic adjunct reduces opioid consumption after cardiac surgery. Anesth Analg 2004;99:1295-301.
Baltali S, Turkoz A, Bozdogan N, Demirturk OS, Baltali M, Turkoz R, et al.
The efficacy of intravenous patient-controlled remifentanil versus morphine anesthesia after coronary artery surgery. J Cardiothorac Vasc Anesth 2009;23:170-4.
Munro AJ, Long GT, Sleigh JW. Nurse-administered subcutaneous morphine is a satisfactory alternative to intravenous patient-controlled analgesia morphine after cardiac surgery. Anesth Analg 1998;87:11-5.
Koukis I, Argiriou M, Dimakopoulou A, Panagiotakopoulos V, Theakos N, Charitos C, et al.
Use of continuous subcutaneous anesthetic infusion in cardiac surgical patients after median sternotomy. J Cardiothorac Surg 2008;3:2.
Liu SS, Richman JM, Thirlby RC, Wu CL. Efficacy of continuous wound catheters delivering local anesthetic for postoperative analgesia: A quantitative and qualitative systematic review of randomized controlled trials. J Am Coll Surg 2006;203:914-32.
Joshi GP, Bonnet F, Shah R, Wilkinson RC, Camu F, Fischer B, et al.
A systematic review of randomized trials evaluating regional techniques for postthoracotomy analgesia. Anesth Analg 2008;107:1026-40.
Møiniche S, Mikkelsen S, Wetterslev J, Dahl JB. A qualitative systematic review of incisional local anaesthesia for postoperative pain relief after abdominal operations. Br J Anaesth 1998;81:377-83.
Møiniche S, Jørgensen H, Wetterslev J, Dahl JB. Local anesthetic infiltration for postoperative pain relief after laparoscopy: A qualitative and quantitative systematic review of intraperitoneal, port-site infiltration and mesosalpinx block. Anesth Analg 2000;90:899-912.
White PF, Rawal S, Latham P, Markowitz S, Issioui T, Chi L, et al.
Use of a continuous local anesthetic infusion for pain management after median sternotomy. Anesthesiology 2003;99:918-23.
Marret E, Bazelly B, Taylor G, Lembert N, Deleuze A, Mazoit JX, et al.
Paravertebral block with ropivacaine 0.5% versus systemic analgesia for pain relief after thoracotomy. Ann Thorac Surg 2005;79:2109-13.
Bainbridge D, Martin JE, Cheng DC. Patient-controlled versus nurse-controlled analgesia after cardiac surgery – a meta-analysis. Can J Anaesth 2006;53:492-9.
Gurbet A, Goren S, Sahin S, Uckunkaya N, Korfali G. Comparison of analgesic effects of morphine, fentanyl, and remifentanil with intravenous patient-controlled analgesia after cardiac surgery. J Cardiothorac Vasc Anesth 2004;18:755-8.
Radvansky BM, Shah K, Parikh A, Sifonios AN, Le V, Eloy JD, et al.
Role of ketamine in acute postoperative pain management: A narrative review. Biomed Res Int 2015;2015:749837.
Subramaniam K, Subramaniam B, Steinbrook RA. Ketamine as adjuvant analgesic to opioids: A quantitative and qualitative systematic review. Anesth Analg 2004;99:482-95, table of contents.
Laskowski K, Stirling A, McKay WP, Lim HJ. A systematic review of intravenous ketamine for postoperative analgesia. Can J Anaesth 2011;58:911-23.
Elia N, Tramèr MR. Ketamine and postoperative pain – a quantitative systematic review of randomised trials. Pain 2005;113:61-70.
Himmelseher S, Ziegler-Pithamitsis D, Argiriadou H, Martin J, Jelen-Esselborn S, Kochs E, et al.
Small-dose S(+)-ketamine reduces postoperative pain when applied with ropivacaine in epidural anesthesia for total knee arthroplasty. Anesth Analg 2001;92:1290-5.
Jaksch W, Lang S, Reichhalter R, Raab G, Dann K, Fitzal S, et al.
Perioperative small-dose S(+)-ketamine has no incremental beneficial effects on postoperative pain when standard-practice opioid infusions are used. Anesth Analg 2002;94:981-6.
Deputy Dean, School of Nursing and Healthcare Professions, Federation University Australia, Office 1121, Building 903, Berwick Campus, PO Box 859, Berwick VIC 3806, 100 Clyde Rd, Berwick
Source of Support: None, Conflict of Interest: None
[Figure 1], [Figure 2], [Figure 3]
[Table 1], [Table 2], [Table 3]