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Effects of glargine insulin on glycemic control in patients with diabetes mellitus type II undergoing off-pump coronary artery bypass graft


1 Department of Cardiac Anesthesia, U N Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India
2 Department of Cardio Vascular and Thoracic Surgery, U N Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India
3 Department of Research, U N Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India

Correspondence Address:
Hemang Gandhi
Department of Cardiac Anesthesia, U N Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aca.ACA_128_17

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Year : 2018  |  Volume : 21  |  Issue : 2  |  Page : 167-172

 

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Background: The prevalence of diabetes mellitus in patients requiring coronary artery bypass grafting (CABG) is noticeably high (20%–30%). These patients have inferior perioperative outcome, reduced long-term survival, and high risk of recurrent episodes of angina. To improve perioperative outcome surgical unit defined satisfactory glycemic control is desired during this period. Hence, the aim of our study is to compare the efficacy of glargine insulin combination with continuous human insulin infusion for perioperative glycemic control in patients with diabetes undergoing CABG. Materials and Methods: Fifty Patients, who were posted for off-pump CABG with diabetes mellitus type II, were randomized in two group, Group I normal saline + human insulin infusion during the perioperative period, Group II (glargine group): Glargine + human insulin infusion during perioperative period. Results: During surgery and in the postoperative period, random blood sugar and human insulin requirement are significantly higher in control group than glargine group. Other infection, step-up antibiotics, intensive care unit (ICU) stay, and hospital stay were significantly higher in control groups in postoperative period. Conclusion: Our study results suggest that glargine effectively manages blood glucose level with significantly greater control over postoperative morbidity.






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1 Department of Cardiac Anesthesia, U N Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India
2 Department of Cardio Vascular and Thoracic Surgery, U N Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India
3 Department of Research, U N Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India

Correspondence Address:
Hemang Gandhi
Department of Cardiac Anesthesia, U N Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aca.ACA_128_17

Rights and Permissions

Background: The prevalence of diabetes mellitus in patients requiring coronary artery bypass grafting (CABG) is noticeably high (20%–30%). These patients have inferior perioperative outcome, reduced long-term survival, and high risk of recurrent episodes of angina. To improve perioperative outcome surgical unit defined satisfactory glycemic control is desired during this period. Hence, the aim of our study is to compare the efficacy of glargine insulin combination with continuous human insulin infusion for perioperative glycemic control in patients with diabetes undergoing CABG. Materials and Methods: Fifty Patients, who were posted for off-pump CABG with diabetes mellitus type II, were randomized in two group, Group I normal saline + human insulin infusion during the perioperative period, Group II (glargine group): Glargine + human insulin infusion during perioperative period. Results: During surgery and in the postoperative period, random blood sugar and human insulin requirement are significantly higher in control group than glargine group. Other infection, step-up antibiotics, intensive care unit (ICU) stay, and hospital stay were significantly higher in control groups in postoperative period. Conclusion: Our study results suggest that glargine effectively manages blood glucose level with significantly greater control over postoperative morbidity.






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