Jennifer Cogan1, Geneviève Lalumière1, Grisell Vargas-Schaffer2, Alain Deschamps1, Zeynep Yegin3
1 Department of Anesthesia, Montreal Heart Institute, Université de Montréal, Montréal, QC, Canada
2 Pain Center of Hôtel-Dieu du CHUM, Université de Montréal, Montréal, QC, Canada
3 Department of Nursing, Montreal Heart Institute, Université de Montréal, Montréal, QC, Canada
Background: Recent meta-analyses have concluded that low-dose intravenous ketamine infusions (LDKIs) during the postoperative period may help to decrease acute and chronic postoperative pain after major surgery. Aims: This study aims to evaluate the level of pain at least 3 months after surgery for patients treated with a postoperative LDKI versus patients who were not treated with a postoperative LDKI. Methods: Administrative and Ethics Board approval were obtained for this study. We performed a retrospective chart review for all patients receiving LDKI, and equal number of age-, sex-, and surgery-matched patients who did not receive LDKI. Low-dose ketamine was prepared using 100 mg of ketamine in 100 ml of normal saline and run between 50 and 200 mcg/kg/h. Results: We reviewed 115 patients with LDKI and 115 without LDKI. The average age was 63.1 years, 73% of the patients were men and sex was evenly distributed between LDKI and non-LDKI. The average duration of the ketamine infusions was 26.8 h with the average dose being 169.9 mg. At an average of 9 months after surgery, 42% of the ketamine group and 38% of the nonketamine group stated that they had had pain on discharge. Of these patients, 30% of the ketamine group and 26% of the nonketamine group still had pain at the time of the phone call. Women in both groups had more acute and chronic pain than men. Conclusion: These results show that LDKI does not promote a decrease in long-term postoperative pain.
Montreal Heart Institute, 5000 Belanger, Montreal, Quebec H1T 1C8
Source of Support: None, Conflict of Interest: None
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