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Troponin elevations in patients with chronic cardiovascular disease: An analysis of current evidence and significance


1 Department of Anesthesiology, Mayo Clinic Florida, FL, USA
2 Department of Anesthesiology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA
3 Department of Anesthesiology and Critical Care Medicine, University of Colorado Hospital, Aurora, CO, USA
4 Division of Cardiovascular and Thoracic Anesthesiology, Mayo Clinic Arizona, AZ, USA

Correspondence Address:
Harish Ramakrishna
Department of Anesthesiology, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9784.179638

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Year : 2016  |  Volume : 19  |  Issue : 2  |  Page : 321-327

 

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Serum troponin elevation above the 99th percentile of the upper reference limit in healthy subjects (<0.01 ng/ml measured using currently available high-sensitivity cardiac troponin laboratory assays) is required to establish the diagnosis the diagnosis of myocardial necrosis in acute cardiovascular syndromes, as well as guide prognosis and therapy. In the perioperative period, for patients with cardiac disease undergoing noncardiac surgery, it is a particularly critical biomarker universally used to assess the myocardial damage. The value of troponin testing and elevation (as well as its significance) in patients with chronic cardiac valvular, vascular, and renal disease is relatively less well understood. This evidence-based review seeks to examine the currently available data assessing the significance of troponin elevation in certain chronic valvular and other disease states.






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1 Department of Anesthesiology, Mayo Clinic Florida, FL, USA
2 Department of Anesthesiology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA
3 Department of Anesthesiology and Critical Care Medicine, University of Colorado Hospital, Aurora, CO, USA
4 Division of Cardiovascular and Thoracic Anesthesiology, Mayo Clinic Arizona, AZ, USA

Correspondence Address:
Harish Ramakrishna
Department of Anesthesiology, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-9784.179638

Rights and Permissions

Serum troponin elevation above the 99th percentile of the upper reference limit in healthy subjects (<0.01 ng/ml measured using currently available high-sensitivity cardiac troponin laboratory assays) is required to establish the diagnosis the diagnosis of myocardial necrosis in acute cardiovascular syndromes, as well as guide prognosis and therapy. In the perioperative period, for patients with cardiac disease undergoing noncardiac surgery, it is a particularly critical biomarker universally used to assess the myocardial damage. The value of troponin testing and elevation (as well as its significance) in patients with chronic cardiac valvular, vascular, and renal disease is relatively less well understood. This evidence-based review seeks to examine the currently available data assessing the significance of troponin elevation in certain chronic valvular and other disease states.






[FULL TEXT] [PDF]*


        
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