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Acute kidney injury following cardiac surgery


1 Department of Internal Medicine/Critical Care, Princess Durru-Shehvar Children's and General Hospital, Purani Haveli, Hyderabad, Andhra Pradesh, India
2 Department of Nephrology, Medwin Hospital, Nampally, Hyderabad, Andhra Pradesh, India

Correspondence Address:
Dilip Gude
Intensivist & Research Coordinator, Department of Internal Medicine/Critical Care, Princess Durru-Shehvar Children's and General Hospital, Purani Haveli, Hyderabad, Andhra Pradesh
India
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Source of Support: Princess Durru-Shehvar Children’s and General Hospital Hyderabad, AP, India, Conflict of Interest: None


DOI: 10.4103/0971-9784.101874

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Year : 2012  |  Volume : 15  |  Issue : 4  |  Page : 279-286

 

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Acute kidney injury (AKI), a recognized complication of cardiac surgery with cardiopulmonary bypass (CPB) is associated with increased morbidity and mortality (15-30%) with approximately 1% of all the affected patients requiring dialysis. Early detection of AKI would enable intervention before occurrence of irreversible injury and might minimize the morbidity and mortality. Recently developed biomarkers of AKI facilitate its earlier discovery and help assessment of its severity and prognosis. In this article, we review the causes of well-known yet inexplicable association between CPB and AKI, the advances in pathophysiologic basis, the diagnostics and the management options.






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1 Department of Internal Medicine/Critical Care, Princess Durru-Shehvar Children's and General Hospital, Purani Haveli, Hyderabad, Andhra Pradesh, India
2 Department of Nephrology, Medwin Hospital, Nampally, Hyderabad, Andhra Pradesh, India

Correspondence Address:
Dilip Gude
Intensivist & Research Coordinator, Department of Internal Medicine/Critical Care, Princess Durru-Shehvar Children's and General Hospital, Purani Haveli, Hyderabad, Andhra Pradesh
India
Login to access the Email id

Source of Support: Princess Durru-Shehvar Children’s and General Hospital Hyderabad, AP, India, Conflict of Interest: None


DOI: 10.4103/0971-9784.101874

Rights and Permissions

Acute kidney injury (AKI), a recognized complication of cardiac surgery with cardiopulmonary bypass (CPB) is associated with increased morbidity and mortality (15-30%) with approximately 1% of all the affected patients requiring dialysis. Early detection of AKI would enable intervention before occurrence of irreversible injury and might minimize the morbidity and mortality. Recently developed biomarkers of AKI facilitate its earlier discovery and help assessment of its severity and prognosis. In this article, we review the causes of well-known yet inexplicable association between CPB and AKI, the advances in pathophysiologic basis, the diagnostics and the management options.






[FULL TEXT] [PDF]*


        
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